Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy
نویسندگان
چکیده
Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed with pore architecture and anisotropic mechanical characteristics that favor skin wound healing reduced scarring. Melt electrowritten mPCL seeded human gingival tissue multipotent mesenchymal stem/stromal cells cryopreserved using a clinically approved method. The regenerative potential of fresh or frozen cell-seeded dressing is compared in splinted full-thickness excisional rat model over six weeks. application decreased contracture significantly improved regeneration through granulation re-epithelialization to control groups. Combining biomimetic precursor cell delivery enhances physiological closure scar formation.
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2021
ISSN: ['0142-9612', '1878-5905']
DOI: https://doi.org/10.1016/j.biomaterials.2020.120558